Глава 12. Беременность: клеточное старение начинается еще в утробе

1. Hjelmborg, J. B., et al., “The Heritability of Leucocyte Telomere Length Dynamics,” Journal of Medical Genetics 52, no. 5 (May 2015): 297–302, doi:10.1136/jmedgenet-2014–102736.

2. Wojcicki, J. M., et al., “Cord Blood Telomere Length in Latino Infants: Relation with Maternal Education and Infant Sex,” Journal of Perinatology: Official Journal of the California Perinatal Association 36, no. 3 (March 2016): 235–241, doi:10.1038/jp.2015.178.

3. Needham, B. L., et al., “Socioeconomic Status and Cell Aging in Children,” Social Science and Medicine (1982) 74, no. 12 (June 2012): 1948–1951, doi:10.1016/j.socscimed.2012.02.019.

4. Collopy, L. C., et al., “Triallelic and Epigenetic-Like Inheritance in Human Disorders of Telomerase,” Blood 126, no. 2 (July 9, 2015): 176–184, doi:10.1182/blood-2015–03–633388.

5. Factor-Litvak, P., et al., “Leukocyte Telomere Length in Newborns: Implications for the Role of Telomeres in Human Disease,” Pediatrics 137, no. 4 (April 2016): e20153927, doi:10.1542/peds.2015–3927.

6. De Meyer, T., et al., “A Non-Genetic, Epigenetic-Like Mechanism of Telomere Length Inheritance?” European Journal of Human Genetics 22, no. 1 (January 2014):10–11, doi:10.1038/ejhg.2013.255.

7. Collopy et al., “Triallelic and Epigenetic-like Inheritance in Human Disorders of Telomerase.” (See #4 above.)

8. Tarry-Adkins, J. L., et al., “Maternal Diet Influences DNA Damage, Aortic Telomere Length, Oxidative Stress, and Antioxidant Defense Capacity in Rats,” FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 22, no. 6 (June 2008): 2037–2044, doi:10.1096/fj.07–099523.

9. Aiken, C. E., J. L. Tarry-Adkins, and S. E. Ozanne, “Suboptimal Nutrition in Utero Causes DNA Damage and Accelerated Aging of the Female Reproductive Tract,” FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 27, no. 10 (October 2013): 3959–3965, doi:10.1096/fj.13–234484.

10. Aiken, C. E., J. L. Tarry-Adkins, and S. E. Ozanne. “Transgenerational Developmental Programming of Ovarian Reserve,” Scientific Reports 5 (2015): 16175, doi:10.1038/srep16175.

11. Tarry-Adkins, J. L., et al., “Nutritional Programming of Coenzyme Q: Potential for Prevention and Intervention?” FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 28, no. 12 (December 2014): 5398–5405, doi:10.1096/fj.14–259473.

12. Bull, C., H. Christensen, and M. Fenech, “Cortisol Is Not Associated with Telomere Shortening or Chromosomal Instability in Human Lymphocytes Cultured Under Low and High Folate Conditions,” PLOS ONE 10, no. 3 (March 6, 2015): e0119367, doi:10.1371/journal.pone.0119367; and Bull, C., et al., “Folate Deficiency Induces Dysfunctional Long and Short Telomeres; Both States Are Associated with Hypomethylation and DNA Damage in Human WIL2-NS Cells,” Cancer Prevention Research (Philadelphia, Pa.) 7, no. 1 (January 2014): 128–138, doi:10.1158/1940–6207.CAPR-13–0264.

13. Entringer, S., et al., “Maternal Folate Concentration in Early Pregnancy and Newborn Telomere Length,” Annals of Nutrition and Metabolism 66, no. 4 (2015): 202–208, doi:10.1159/000381925.

14. Cerne, J. Z., et al., “Functional Variants in CYP1B1, KRAS and MTHFR Genes Are Associated with Shorter Telomere Length in Postmenopausal Women,” Mechanisms of Ageing and Development 149 (July 2015): 1–7, doi:10.1016/j.mad.2015.05.003.

15. “Folic Acid Fact Sheet,” Womenshealth.gov, http://womenshealth.gov/publications/our-publications/fact-sheet/folic-acid.html, accessed November 27, 2015.

16. Paul, L., et al., “High Plasma Folate Is Negatively Associated with Leukocyte Telomere Length in Framingham Offspring Cohort,” European Journal of Nutrition 54, no. 2 (March 2015): 235–241, doi:10.1007/ s00394–014–0704–1.

17. Entringer, S., et al., “Maternal Psychosocial Stress During Pregnancy Is Associated with Newborn Leukocyte Telomere Length,” American Journal of Obstetrics and Gynecology 208, no. 2 (February 2013): 134.e1–7, doi:10.1016/j.ajog.2012.11.033.

18. Marchetto, N. M., et al., “Prenatal Stress and Newborn Telomere Length,” American Journal of Obstetrics and Gynecology, January 30, 2016, doi:10.1016/j.ajog.2016.01.177.

19. Entringer, S., et al., “Influence of Prenatal Psychosocial Stress on Cytokine Production in Adult Women,” Developmental Psychobiology 50, no. 6 (September 2008): 579–587, doi:10.1002/dev.20316.

20. Entringer, S., et al., “Stress Exposure in Intrauterine Life Is Associated with Shorter Telomere Length in Young Adulthood,” Proceedings of the National Academy of Sciences of the United States of America 108, no. 33 (August 16, 2011): E513–518, doi:10.1073/pnas.1107759108.

21. Haussman, M., and B. Heidinger, “Telomere Dynamics May Link Stress Exposure and Ageing across Generations.” Biology Letters 11, no. 11 (November 2015). doi:10.1098/rsbl.2015.0396.

22. Ibid.

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